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Raman-active gold nanoparticles as beacons in breast cancer cells

Raman Microspectroscopy image of HeLa cell incubated with gold nanoparticles

Raman Microspectroscopy image of HeLa cell incubated with gold nanoparticles

HeLa cell analyzed using Vertex Component Analysis (VCA) to identify the subtle subcellular changes induced by nanoparticle internalization. Using pseudo color imaging, information was obtained to locate the nucleus/nucleoli (blue), cytoplasm (green) and a small nanoparticle inclusion (red).

Credits: NSF IGERT trainee Jennifer Monanan and advisor, Prof. Max Diem from IGERT Nanomedicine Science and Technology Program at Northeastern University.