Development of a Probe for Membrane Cholesterol Accessibility

Mon, 02 Dec 2013 19:00:00 -0500

Our primary goal with this research is in the area of research infrastructure – the generation of a new tool for the detection of cholesterol accessibility at the surface of cell membranes. Through this work, we will discover the molecular mechanisms of how water-soluble molecules interact with membrane cholesterol and how cholesterol accessibility regulates cell physiology, enabling new strategies for the treatment of disease.